1,229 research outputs found
Wound bed preparation: A novel approach using HydroTherapy
Wounds that fail to heal quickly are often encountered by community nursing staff. An important step in assisting these chronic or stalled wounds progress through healing is debridement to remove devitalised tissue, including slough and eschar, that can prevent the wound from healing. A unique wound treatment called HydroTherapy aims to provide an optimal healing environment. The first step of HydroTherapy involves HydroClean plusâą, this dressing enables removal of devitalised tissue through autolytic debridement and absorption of wound fluid. Irrigation and cleansing provided by Ringerâs solution from the dressing further removes any necrotic tissue or eschar. Once effective wound bed preparation has been achieved a second dressing, HydroTacâą, provides an ongoing hydrated wound environment that enables re-epithelialisation to occur in an unrestricted fashion. This paper presents 3 case studies of slow healing wounds treated with HydroClean plusâą which demonstrates effective wound debridement
Computational Controversy
Climate change, vaccination, abortion, Trump: Many topics are surrounded by
fierce controversies. The nature of such heated debates and their elements have
been studied extensively in the social science literature. More recently,
various computational approaches to controversy analysis have appeared, using
new data sources such as Wikipedia, which help us now better understand these
phenomena. However, compared to what social sciences have discovered about such
debates, the existing computational approaches mostly focus on just a few of
the many important aspects around the concept of controversies. In order to
link the two strands, we provide and evaluate here a controversy model that is
both, rooted in the findings of the social science literature and at the same
time strongly linked to computational methods. We show how this model can lead
to computational controversy analytics that have full coverage over all the
crucial aspects that make up a controversy.Comment: In Proceedings of the 9th International Conference on Social
Informatics (SocInfo) 201
Reply to comment by P. Riley and J. T. Gosling on âAre highâlatitude forwardâreverse shock pairs driven by overexpansion?â
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95455/1/jgra18795.pd
Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting
Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related viruses with pandemic potential. Here we leverage rational immunogen design to focus humoral responses on conserved epitopes. Using glycan engineering and epitope scaffolding in boosting immunogens, we focus murine serum antibody responses to conserved receptor binding motif (RBM) and receptor binding domain (RBD) epitopes following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike imprinting. Although all engineered immunogens elicit a robust SARS-CoV-2-neutralizing serum response, RBM-focusing immunogens exhibit increased potency against related sarbecoviruses, SARS-CoV, WIV1-CoV, RaTG13-CoV, and SHC014-CoV; structural characterization of representative antibodies defines a conserved epitope. RBM-focused sera confer protection against SARS-CoV-2 challenge. Thus, RBM focusing is a promising strategy to elicit breadth across emerging sarbecoviruses without compromising SARS-CoV-2 protection. These engineering strategies are adaptable to other viral glycoproteins for targeting conserved epitopes
Light dark matter in the NMSSM: upper bounds on direct detection cross sections
In the Next-to-Minimal Supersymmetric Standard Model, a bino-like LSP can be
as light as a few GeV and satisfy WMAP constraints on the dark matter relic
density in the presence of a light CP-odd Higgs scalar. We study upper bounds
on the direct detection cross sections for such a light LSP in the mass range
2-20 GeV in the NMSSM, respecting all constraints from B-physics and LEP. The
OPAL constraints on e^+ e^- -> \chi^0_1 \chi^0_i (i > 1) play an important role
and are discussed in some detail. The resulting upper bounds on the
spin-independent and spin-dependent nucleon cross sections are ~ 10^{-42}
cm^{-2} and ~ 4\times 10^{-40} cm^{-2}, respectively. Hence the upper bound on
the spin-independent cross section is below the DAMA and CoGeNT regions, but
could be compatible with the two events observed by CDMS-II.Comment: 17 pages, 3 figure
Limits on the Majorana neutrino mass in the 0.1 eV range
The Heidelberg-Moscow experiment gives the most stringent limit on the
Majorana neutrino mass. After 24 kg yr of data with pulse shape measurements,
we set a lower limit on the half-life of the neutrinoless double beta decay in
76Ge of T_1/2 > 5.7 * 10^{25} yr at 90% C.L., thus excluding an effective
Majorana neutrino mass greater than 0.2 eV. This allows to set strong
constraints on degenerate neutrino mass models.Comment: 6 pages (latex) including 3 postscript figures and 2 table
An exploration of cognitive subgroups in Alzheimer's disease
Heterogeneity is observed in the patterns of cognition in Alzheimer's disease (AD). Such heterogeneity might suggest the involvement of different etiological pathways or different host responses to pathology. A total of 627 subjects with mild/moderate AD underwent cognitive assessment with the Mini-Mental State Examination (MMSE) and the Dementia Rating Scale-2 (DRS-2). Latent class analysis (LCA) was performed on cognition subscale data to identify and characterize cognitive subgroups. Clinical, demographic, and genetic factors were explored for association with class membership. LCA suggested the existence of four subgroups; one group with mild and another with severe global impairment across the cognitive domains, one group with primary impairments in attention and construction, and another group with primary deficits in memory and orientation. Education, disease duration, age, Apolipoprotein E-Δ4 (APOE Δ4) status, gender, presence of grasp reflex, white matter changes, and early or prominent visuospatial impairment were all associated with class membership. Our results support the existence of heterogeneity in patterns of cognitive impairment in AD. Our observation of classes characterized by predominant deficits in attention/construction and memory respectively deserves further exploration as does the association between membership in the attention/construction class and APOE Δ4 negative status. (JINS, 2010, 16, 233-243.
Neutrino masses from new generations
We reconsider the possibility that Majorana masses for the three known
neutrinos are generated radiatively by the presence of a fourth generation and
one right-handed neutrino with Yukawa couplings and a Majorana mass term. We
find that the observed light neutrino mass hierarchy is not compatible with low
energy universality bounds in this minimal scenario, but all present data can
be accommodated with five generations and two right-handed neutrinos. Within
this framework, we explore the parameter space regions which are currently
allowed and could lead to observable effects in neutrinoless double beta decay,
conversion in nuclei and experiments. We
also discuss the detection prospects at LHC.Comment: 28 pages, 4 figures. Version to be published. Some typos corrected.
Improved figures 3 and
Participation in boys and girls clubs: motivation and stage environment fit
This article presents the results of semi-structured in-depth interviews conducted with 54 youth attending six elementary school-based and middle school-based Boys and Girls Clubs in two low-income communities. The first goal of this study was to examine why youth choose to participate in these clubs. The most commonly reported motives include fun activities, opportunities to be with friends, parent has to work, and getting help with homework. The second goal was to examine youths' perceptions of staff, peers, activities, and the extent to which clubs are organized in a way to support the need for relatedness, competence, and autonomy. Variations in youths' perceptions of the quality of relationships with staff and peers, level of interest and challenge, and opportunities for decision making, by developmental level (elementary versus middle school) are discussed. Implications of our findings for sustaining youths' interest and continued involvement in out-of-school youth development programs are highlighted. © 2010 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69176/1/20369_ftp.pd
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